Short-acting analogs: Onset - 15 min. Peak - 1-2 hrs. Duration: 4-6 hrs.

Reg.: Onset - 30 - 60 min. Peak:2-4 hrs. Duration: 6-8 hrs.

Glargine: Onset - 2-4 hrs.  Peak: flat.  Duration: 24 hrs

R

Insulin analogues offer a much more physiologic insulin profile than do older insulin preparations and allow development of a treatment strategy that gives patients much more dietary freedom using a basal-bolus insulin with carbohydrate counting.

CSII provides the ultimate in physiologic insulin delivery and will soon be linked to a continuous glucose monitoring technology that brings insulin treatment closer to the dream of a closed loop system or “artificial pancreas”.