Concept of type 2 diabetes however, changing…It became a part of metabolic syndrome now…Insulin resistance is basic abnormality of this disease, type 2 diabetes is in many occasion, a part of the syndrome. It is not a disease of glucose…but one manifestation of disease, metabolic syndrome. What is it? My understanding is that there is basic abnormality of insulin resistance, and insulin act to compensate this abnormality, and metabolic syndrome is resulting phenotype. Then question become what this basic abnormality is?