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National Biomedical Research Foundation (NBRF) => Protein Identification Resource (PIR)
Margaret Dayhoff
Atlas of Protein Sequences
Phylogenies, evolution, amino acid substitution matrices (PAM) and discovering active sites in enzymes
PIR SF Evolutionary Family , iProClass Functional site analysis and ontologies , iProLink to literature
UniProt - Universal Protein Resource
Amos Bairoch
Manual curation and annotation
Highly cross-referenced
Many useful analytical tools (EXPASY Tools)
2D-PAGE and Mass Spectrometry databases
Prosite functional motif database
UniProt - Universal Protein Resource
TREMBL
Translation of mRNAs (RefSeq), UniGene, open reading frames (ORFs) and predicted genes from genomes
Automatic annotations
Interpro linked to domain and motif databases (CATH , PANTHER , PRINTs, PROSITE, pFAM, PIRSF, PRODOM, SCOP, SMART, SUPERFAMILY)
Intron-exon structure and links to ORFs, coding regions
UniProt - Universal Protein Resource
Protein and nrPRO database SwissProt, PIR and translated genes/genomes
Linked to coding regions and intron/exon structure
Linked to coding SNPs and variations databases
Linked to 3D domains