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Usually fatal. Two main forms are seen:

Furious: Most common form in canidae, felidae and mustelidae: abnormal aggression, drool excessive saliva, attack without provocation. Territorial behaviour diminished resulting in disordered wandering. Inco-ordination, convulsions, coma and death follow within 3 - 10 days.

Dumb or paralytic: Most common in ruminants and horses but does also occur in dogs: paralysis of the lower jaw and drooling saliva, tremors and progressive paralysis then coma and death. In cattle there is ruminal tympany, tenesmus, sometimes diarrhoea. In dogs, a change in voice may be noted in howling or bellowing.

Hydrophobia: Seen only in man.