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- The incubation
period is 2-8 years with a peak disease at 5.5years old. Cattle breeds do not show
differing incubation periods. - Histological findings include: vacuolation of the neurones and neuronal ground substance in cerebella/cortex; perivascular fibrils of amyloid in which PrPsc can be demonstrated by immunostaining and congo red bifringence; astrocyte infiltration. - The clinical signs are apprehension, hyperaesthesia, frequent licking with progressive paresis, and ataxia. No blindness or circling. (At the London Zoo it was first noticed by the public when a Puma became ataxic). |