Some scientists and health professionals doubt that genetic testing will help prevent chronic diseases, such as T2D for a variety of reasons.  First, the predictive value of most genetic tests is low, and risk estimates do not account for well-known environmental determinants of the disease.  Secondly, it is unclear whether knowledge about one’s genetic risk will increase motivation to engage in disease interventions.  Thirdly, genetic testing presents education and information-dissemination challenges that were outlined in detail by the Secretary’s Advisory Committee on Genetics, Health and Society. Fourthly, most health professionals are currently unqualified to interpret the results of genetic tests.  Fifthly, genetic testing may lead to significant distress, the magnitude of which is likely to vary as a function of test results, coping skills, risk perception and other characteristics.  These factors relate directly to other concerns such as insurance and employment discrimination, confidentiality and stigmatization based on knowing that one is at high genetic risk.