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Tissue infection by dengue 2 viruses peaks just
after viremia ends. In humans vascular permeability occurs at about the time
that viremia ends (defervescence) and cellular infection is maximal based
upon the monkey model (Marchette et al JID 128:23-30, 1973; Halstead SB in
Schlesinger WR Togaviruses Academic Press NY 1980. pp 107-73). |