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The epidemiological observations from Iquitos
in 1995 can be explained by the laboratory findings summarized in this
slide. Other workers hypothesize that American genotype dengue 2 is
replication defective producing low titered infections in mosquitoes and in
humans. However, this virus has been circulating in the Americas for
possibly hundreds of years and arrived in Peru earlier than did the
allegedly more replication-competent Asian dengue 2 virus (Rico-Hesse R.
Microevolution and virulence of dengue viruses. Adv Virus Res 59: 315-341,
2003)
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