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During the 20th century, the decline of infectious disease mortality has been the most important cause of increased life-expectancy. Infectious disease as a cause of illness and death in the 1920s and 1930s was of huge importance. Although the introduction of immunizing agents, suiphonamides and antibiotics have had an enormous impact, new problems have arisen, such as antibiotic resistant organisms, and new conditions such as AIDS and Legionella. The decline in respiratory mortality was second in importance. There have also been major declines in death rates for the diseases of the digestive, genito-urinary and nervous systems. One of the most dramatic changes over the years in the question has been the reduction in maternal, infant and child mortality. As against these declines there have been increases in mortality for circulatory diseases and cancers.