||But there was no such increased susceptibility
after downregulation of bcl-2 by dexamethasone (113, 114) owing to
upregulation of another apoptosis suppressing gene bcl-XL (114). Apoptosis
is controlled by the balance between apoptosis inducing and
apoptosis-suppressing genes. To increase cancer cell susceptibility to
induction of apoptosis, it will be necessary to select the appropriate
compound for downregulation of those apoptosis-suppressing genes that
suppress apoptosis in a particular cancer.