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Let’s review the basic science of resistance briefly.
How does resistance develop?
It is genetic.
Resistance genes certainly occur naturally.
(The definition of an antibiotic is a naturally produced
substance which and antimicrobial activity).
There are three basic mechanisms by which resistance
genes work:
1. They encode for
enzymes that degrade the antibiotic,
2. They encode for
changes in the site of action, or
3. They encode for
molecular mechanisms to prevent entry or speed exit of the
antibiotic from the cell
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