front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |29 |30 |31 |32 |33 |34 |35 |36 |37 |38 |39 |40 |41 |42 |43 |44 |45 |46 |47 |48 |49 |review

This graphs shows the second order relationship of LDL+HDL and cardiovascular event risk reduction, using data from major clinical trials of lipid-lowering therapy. The percent change from baseline (or placebo) for LDL+HDL is added using absolute values. This is plotted against the relative risk reduction in composite endpoints from each of the trials. The trend line indicates that these variables are highly correlated. In fact, it appears that the percent absolute change in LDL+HDL during treatment in these clinical trials accounts for 76% of the effect on cardiovascular event relative risk reduction vs placebo in this crude analysis.