Genetic susceptibility may also account for multiple cancers outside of high-risk families. Hot off the press is this comprehensive monograph, a study led by Rochelle Curtis on the risks of second cancers developing in the U.S. population covered by the SEER program of NCI. Some of the constellations of cancer resembled the patterns seen in the genetic syndromes such as hereditary non-polyposis colon cancer (or Lynch syndrome). However, other combinations do not conform to known syndromes yet the early onset of tumors and their reciprocal associations with one another suggest that shared susceptibility mechanisms may be involved.