More persuasive evidence for the environment comes from the dramatic shifts in cancer risk among migrant populations. In studies of breast cancer in Asian Americans led by Regina Ziegler we found that the risks varied by six-fold, being lowest when migrants and all 4 grandparents on the—on the left were born in rural parts of the East and lived less than 8 years here in the West, and highest when migrants were born in the West along with at least 3 grandparents. In the last group, the incidence rates are as high as the rates in the U.S. white population. And the factors underlying this migrant effect are not entirely clear, but they appear related at least partly to changing reproductive histories and endogenous hormones, increases in body weight and height, and dietary factors. We’re not sure about dietary fat which Alice Whittemore mentioned this morning, but we have seen a—what appears to be a protective effect of soy, especially when consumed during the childhood years.