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Alternating pressure systems contain air-filled chambers or cylinders arranged lengthwise, interdigitated, or in various other patterns. Air is pumped into the chambers at periodic intervals to inflate and deflate the chambers in opposite phases thereby changing the location of the contact pressure. Pulsating pressure differs from alternating therapy in that the duration of peak inflation is shorter and the cycling time is more frequent. The latter appears to have a dramatic effect on increasing lymphatic flow .

The concept of alternating pressure for prevention of tissue ischemia is not new. Kosiak concluded in 1961 that "since it is impossible to completely eliminate all pressure for a long period of time, it becomes imperative that the pressure be completely eliminated at frequent intervals in order to allow circulation to the ischemic tissue". Houle's conclusion that a dynamic device that alternately shifts the pressure from one area to another would be "the choice to provide adequate protection against the development of ischemic ulcers" has been supported over the years by many others (Kosiak, 1976; Souther, Carr & Vistnes, 1974; Seymour, 1985; . Rather than increasing the surface area for distribution through immersion and envelopment, alternating pressure devices distribute the pressure by shifting the body weight to a different surface contact area. This may increase the interface pressure of that area during the inflation phase.