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The human population is growing exponentially, with virtually all of this growth occurring in urban zones. Compounding this problem, there is more population movement between urban centers within and among countries, more substandard housing, more artificial disposable containers and governmental services that are inadequate in these burgeoning urban centers. As a result of these changes, the resurgence of Aedes aegypti (dengue fever) is presently much greater than it has been in the past. Worldwide, up to 100 million people annually are infected with dengue fever, mainly in tropical cities and urban areas, while 2.5 billion people are at risk of infection.

Human mobility and intervention also can be important for their role in introducing virus into susceptible populations. Increased air travel between urban centers of the tropics has been cited as a factor responsible for the increased frequency of dengue epidemics. The geographic dissemination and endemic maintenance of dengue fever in the Americas and the Caribbean depends on the continued introduction of virus into susceptible human populations, spread within these populations, and low-level transmission during non-epidemic periods.