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为了考查高密度脂蛋白类胆固醇与冠心病是否受其他危险因子的影响,Gordon等人基于四项美国心血管研究:Framingham Heart StudyFHS),Lipid Research Clinics Prevalence Mortality Follow-up Study (LRCF)Lipid Research Clinics Coronary Primary Prevention Trial (CPPT)Multiple Risk Factor Intervention TrialMRFIT),分析了HDL-C和冠心病发病率(与年龄,血压,吸烟,体重指标及低密度脂蛋白类胆固醇有关)之间的关系。HDL-C水平降低1mg/dL可以显著引起男性患冠心病的危险降低2%FHSCPPTMRFIT)女性降低3%FHS)。在这张幻灯片中LRCF的回归系数主要是由关心病的死亡率引起因为那项研究只列举了最关键的结果。
参考文献:
1. Gordon DJ, Probstfield JL, Garrison RJ, et al. High-density lipoprotein cholesterol and cardiovascular disease: four prospective American studies. Circulation. 1989;79:815.