It could be that improved glycaemic control significantly reduced microvascular diseases, but not macrovascular. In this slide the risk of myocardial infarction on the one hand and microvascular diseases on the other are related to mean of glycated hemoglobin during entire study. What this implies is that the expected benefit for glycemia improvement as for microvascular disease is concerned is much greater that may be expected for large vessels disease and this indeed is what the intervention part of the study shows. The UKPDS, even with 5000 patients, was underpowered to detect the significant benefit of glycaemic control on large vessels diseases.