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Let me now introduce the theme of my talk. I am going to start by considering the concept of risk factors and cardiovascular risk in diabetic subjects. I am going to talk about the evidence, about intervention for glucose lowering, for blood pressure and for lipid management in preventing cardiovascular disease in patients with diabetes. I am going to discuss primary and secondary prevention in diabetic subjects and look at what evidence based that is for management. I will talk specifically about the case of therapy with aspirin. I will finish by suggesting that we should be considering the levels of absolute risk rather the levels of risk factors, when deciding whether to initiate or alter treatment in these patients.