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Corrao, et al (2004) recently reviewed the dose–risk relationship between alcohol consumption and major alcohol-related diseases. The review found that in general, disease risks begin to rise with any drinking and increase further with higher intake.  Risk increases significantly for drinkers, beginning at an intake of 25 g per day, for cancers of the oral cavity and pharynx, esophagus, larynx, breast, liver, colon, and rectum, as well as liver cirrhosis, hypertension, chronic pancreatitis, and injuries and violence. The risk of hemorrhagic stroke increases significantly at 50 g per day and 100 g per day. The risk of ischemic stroke increases at 100 g per day.  Coronary heart disease risk decreases significantly at 25 g per day and 50 g per day, and increases at 100 g per day.