Presence of co-morbidity that could affect drug choice, such as tuberculosis, hepatitis B or C infection, or chronic renal or liver disease (for example, coadministration of rifampin can significantly reduce drug levels of nevirapine and most protease inhibitors; viral hepatitis can predispose to hepatic toxicity of nucleoside and non-nucleoside antiretroviral drugs; and, depending upon the route of metabolism/excretion for individual drugs, dose modification may be required for individuals with significant renal/liver disease);
Potential antiretroviral drug interactions with other medications required by the child; and
The ability of the caregiver and child to adhere to the regimen.