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In 1999, 659,441 chlamydial infections were reported to CDC. From 1987 through 1999 the reported rate of chlamydial infection among women increased from 78.5 cases per 100,000 population to 404.5. These increases in the reported national chlamydia rate likely represent increased chlamydia screening, increased use of more sensitive testing methods, improved reporting as well as the continuing high burden of disease (Chlamydia Prevalence Monitoring Project, CDC, November 2000).

As screening sites are usually set up to test women, chlamydia in men is under reported. Many health care providers will treat men presenting with symptoms such as discharge and burning on urination with antibiotics based on a diagnosis of urethritis. These antibiotics usually cure a chlamydial infection and testing and reporting does not occur.