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Either Herpes simplex I or II may infect the genital tract or oral mucosa. Primary and recurrent infections occur with or without symptoms.

50%-90% of adults worldwide possess circulating antibodies to HSV 1.

20%-30% of American adults possess circulating antibodies to HSV 2. Up to 60% in persons with multiple sexual partners.

66% of the population has HSV-1, the usual cause of oral herpes.