Perhaps in Burr’s subjects with chronic angina there was extensive ischemia and fibrosis with partially depolarized myocytes in a large proportion of the ventricular myocardium so their cardiac function was dependent on the contraction of these partially depolarized myocytes. Then an increased intake of fish oil might eliminate the function of these partially depolarized heart cells and the vital pumping function of the heart would also be eliminated. We have asked Burr to have the autopsy findings examined on the hearts of patients who died in his study. He reported to us that the pathology showed just what we expected, namely extensive ischemia and fibrosis through out much of the myocardium. An even more recently published paper has apparently encountered the same difficulty as Burr and associates did, judged by the high proportion (62%) of their subjects receiving the fish oil supplement, who had NYHA functional class iii and iv congestive heart failure.