||c) The n-3 EPA and DHA each modulate several
ion currents, whereas pharmaceutical drugs tend to be specific for a single
or couple of cardiac ion channels so that it requires a number of drugs
acting together to inhibit the same group of ion channels.
d) The drugs act on heart cells to increase the number of ion channels
per cardiomyocyte through an effect of the drug on sodium channel gene
expression, whereas the n-3 fish oils do not induce such an action, as we
have reported comparing mexiletine and EPA on cultured rat heart cells. f)
It seems appropriate with the drugs to refer to their physiological effects
as blocking or inhibitory, since they are capable of eliminating physiologic
effects, whereas the n-3 fatty acids modulate action in a gentler manner as
they reduce but do not seem to eliminate physiologic or biochemical
processes in our bodies.