front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |review

Also, these partially depolarized cells have Na+ channels, which in milli-seconds can slip into “resting inactivation” in response to sub-threshold depolarizations without eliciting an action potential and do this even faster in the presence of the fish oil fatty acids. The results of these effects of the n-3 PUFAs are that these partially depolarized myocytes are quickly made inexcitable and their potential arrhythmic mischief is aborted. Myocytes with normal membrane potentials in the nonischemic myocardium will not be so drastically affected by the PUFAs and will continue to function normally. This latter point I would like to clarify with the experiment shown in Figure 7.