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The inheritance of each dose of E4 = epsilon 4 increases the risk and lowers the age of onset distribution for AD; epsilon 2 has lower risk. APOE4 has a high positive predictive value for AD. See http://www.jbc.org/cgi/reprint/276/16/12945 Apolipoprotein E is a major component of specific lipoproteins called very low-density lipoproteins (VLDL). A key function of VLDLs is to remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of disorders that affect the heart and blood vessels (cardiovascular diseases), including heart attack and stroke.