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In Veteran administration study for Hypertensive efficacy, impotence was observed 29% in intervention group & 28% in comparison group. If there is no comparison group, it may be erroneously considered that hypertensives will cause impotence

In Aspirin Myocardial Infarction Study (AMIS 1980) complaints of gastritis and peptic ulcer were reported 23.7% and 14.9% in intervention and comparison groups respectively, thereby lessening the blame on Aspirin.