prev next front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |review
A robust epidemiological feature of schizophrenia is the slight excess of births in winter and spring in the temperate regions of the Northern Hemisphere. This points towards a risk factor (such as lower winter sunlight or increased winter infection) operating pre- or peri-natally rather than around the time of onset,
Also, while the seasonal excess is small it may have a larger impact. For example, a comprehensive Danish record-linkage study found that the small seasonal excess of schizophrenia births (relative risk = 1.11) was associated with a sizeable (10.5%) population attributable fraction (PAF) for the disorder. The reason for this high PAF is that birth in winter or spring is a common exposure.
In other words, because so many people are born winter or spring, a relatively small increase in risk would cause a large increase in the numbers of people with the schizophrenia.