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The choice of analytical design depends upon the feasibility, the setting and the requirements of the study.

Both the case control and cohort designs are having their own merits and demerits.

While the bias is the main problem with the former, follow up , attrition and ethical problems are the hurdles for the latter.

Some believe that case control study is the initial step for establishing causality later to be followed by cohort study.

But case control technique will be uniquely useful in certain circumstances.