mechanism of MS
Accumulation of visceral fat may be
involved in the upstream of clustering of multiple risk factors. Visceral
fat accumulation is influenced by environmental and genetic factors.
Visceral fat is a very active tissue in terms of lipogenesis and lipolysis.
The FFAs released from visceral adipose tissues such as mesenteric and
omentum fat enter the portal vein, leading to enhanced lipoprotein synthesis
and hyperlipidemia. TNF-alpha released from visceral fat may cause insulin
resistance and impaired glucose metabolism. Adipose tissues secrete a
variety of bioactive substances named adipocytokines. PAI-1 synthesized from
visceral fat may directly lead to a prothrombotic state. Visceral fat
accumulation causes a reduction of serum adiponectin, an adipocyte-derived
protein with distinct anti-atherosclerotic effects and can improve insulin
resistance. Dysregulation of adipocytokies may lead to insulin resistance
and the clustering of multiple risk factors may cause atheroslcerotic CVD.