• Good antibody levels are achieved within 10-15 days.
• Protection lasts for 3 years.
• A & C decline markedly after the first 3 years of vaccination.
• Antibody decline is more rapid in infants and children.

• mild and infrequent
• localized erythema
• transient fever

Revaccinations:

• children under 4 years of age who were first immunized

Stability:

• Shelf life at 2-8⁰ C = 2 years
• After reconstitution = 5-6 hours