Thiacetarsamide (2.2 mg/kg, 4 IV doses over 2 days) will kill most male and some female worms but has poor efficacy against immature and young female worms.

Melarsomine (2.5 mg/kg, 2 IM doses over 24 hr) has improved efficacy (>95 % kill). However, increased worm death can cause serious complications. One IM dose followed 1 month later by 2 IM doses is a safer alternative.