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This site binds to
a portion of the antigen known as an antigenic determinant or epiitope.
Successful binding of the antigen receptor to the epitope, when accompanied
by
additional signals,
results in: 1/ stimulation of the cell to enter the
cell cycle,
and 2/ repeated
mitoses
that lead to the development of a
clone
of cells bearing the same antigen receptor. Monoclonal means all the same
belonging to the identically initiated cell cycle. BCRs and TCRs differ in their structure, the genes that encode them and the type of epitope to which they bind.
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