The importance of obtaining a proper diagnosis is related to the fact that anticoagulant therapy inherently carries the risk for hemorrhagic complications. This risk is by no means negligible. Furthermore, in patients who are suspected of VTE, only 25-30% will have their diagnosis confirmed by objective diagnostic tests. Hence, it is equally important to exclude the disease, so that anticoagulant therapy (and its complications) can be withheld from patients without VTE.