The structure of the Collaboration consists of the following components:

Collaborative Review Groups (CRGs) - Contain researchers healthcare professionals and consumers interested in particular health conditions or diseases. There are 50 CRGs.
Methods Groups - Exist to improve the methodology of systematic reviews.
Fields - Focus on dimensions of health care other than health problems such setting (e.g., primary care), defined population (e.g., older people), or intervention (e.g., vaccines).
Consumer Network - Provides information and a forum for networking for consumers involved in the Collaboration.
Centres - Supports the work of the above entities in 12 Centres around the world.