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The incidence of anaphylaxis has been very difficult to determine because of limited recognition and reporting by emergency departments and physicians in general. Only very recently has there been a published report of a careful epidemiologic study of the reported occurrences of anaphylaxis over a specific time period in a closed population. In this study, Yocum et al at the Mayo Clinic identified the onset of anaphylaxis in 21 per 100,000 person-years. If this is projected as a national average, then approximately 63,000 new cases of anaphylaxis would be reported each year in the United States.

More recently, a study by Bohlke et al reported an incidence of 10.5 per 100,000 person-years among children age 0-17 years.