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T-Cells train in Thymus. Involved in cell-mediated immunity: basically, hand-to-hand combat.

Many kinds: CD34, CD38, etc

Two of interest: CD4 and CD8 In HIV CD4 goes down and CD8 goes up.

  • Nl CD4 about 600-1200/mm3.
  • 2. Function important, but canít tell from #ís
  • 3. CD4 at type of lymphocyte. Absolute vs %
  • Daily, hourly fluctuation.
  • CD4:CD8 normally 2:1. Reverses in HIV as probable compensation.
  • CD4 count usually lags behind VL, but good indicator of when to start treatment