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Horses and humans are the species most susceptible to the toxin. Tetanus toxoid (vaccine) is given IM initially as doses 3-6 weeks apart followed by an annual booster. Tetanus antitoxin (serum) also works against the toxin, but is only effective for 2-3 weeks. Antitoxin is best used when the vaccination history of an injured animal is unknown, in unvaccinated mares at foaling and for newborn foals born to unvaccinated mares. The first tetanus toxoid injections could be given at 1-3 months of age.