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|This is the
second of a three-part lecture characterizing the toxicity,
bioaccumulation, and persistence properties of environmental endocrine
disruptors (EEDs). The characterization is primarily from a health risk
assessment perspective. Therefore, the effects and properties so
characterized are mainly those pertinent to exposure and risk significance,
rather than those dealing with adverse health effects, of which endocrine
disruption is an important type. The lecture’s overall objective is to
convey the concept that even for a short duration, exposure to a persistent
bioaccumulative EED of low disruption potency could lead to a severe health
To facilitate the characterization so promised,Part I presents an overview of the human endocrine system and the basic mechanisms of endocrine disruption. It then concludes with a literature review to ascertain the effects of endocrine disruption as a major health problem.
This Part II reviews the factors fundamental to a substance’s fate and bioaccumulation in the environment. Another effort of Part II is to provide some evidence from the literature on bioaccumulation and long-range transport. These literature data are intended to support the asseveration that many endocrine disruptors are highly bioaccumulative.