Physical activity interventions are underway that may demonstrate a positive effect of physical activity on cancer-related fatigue. Similarly, diet, weight or physical activity interventions may enhance self-image among survivors (86,87). Cancer treatment can also alter sexual function directly, make the patient feel less attractive thereby diminishing sexual desire and suppress gonadal function leading to ovarian failure and the development of osteoporosis. Exercise and nutrition interventions may be effective in ameliorating such potential adverse health consequences and warrant further research.