prev next front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |review
Small cell lung cancer:

classical cell line (70%) with well-defined neuroendocrine features, a low colony-forming efficiency, and highly responsive to chemo- and radiotherapy;

variant cell line (30%), with loss of neuroendocrine features, a high colony-forming efficiency, poorly responsive to chemo- and radiotherapy, and morphologically resembling the large cell undifferentiated large cancer type. This type is associated with overexpression of the c-myc oncogene.

Evolution of small cell lung cancer from classical to variant type may occur as a natural event, be induced by therapy or as a result of genetic developments and interaction between myc-oncogenes and Harvey-ras oncogenes.