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Cancer cells not only divide when they shouldnít but they also reproduce with far poorer fidelity than normal cells. Chromosome aberrations and chromosome losses are very common in cancer cells. This loss of fidelity seemed central to cancer because it would permit the cancer cells to evolve more quickly. We thought we might be able to learn more about how chromosome fidelity is maintained in the normal cell cycle by studying the fidelity of chromosome transmission in yeast cells.