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The intent of this first lecture of the series is to teach the students the very close and basic relationship between epidemiology and toxicology, and hence the very existence of toxicologic epidemiology, which is now a silent but growing field in public health. To this end, the students are asked to simply revisit the mission of public health, the concept of health risk assessment, and the scope and definition of toxicology and of epidemiology. Upon learning the existence of toxicologic epidemiology from such a theoretical construct, the students are urged to learn, later on in the remaining lectures, the in-dept principles and application of this growing field.