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cannot be visualized by light microscopy but can be seen using darkfield
Serologic testing is an indirect method of diagnosis since it relies upon a maternal humoral immune response to the infection.
Two types of serologic testing are available:
Nontreponemal Antibody tests (Venereal Disease Research Laboratory(VDRL) and the Rapid Plasma Reagin (RPR)- are performed on serum and used as the screening tests for syphilis.
Treponemal Antibody tests (Fluorescent Treponemal Antibody Absorption (FTA-ABS) and microhemagglutination test for antibodies to T. pallidum (MHA-TP) are confirmatory tests that detect antibodies specifically directed at treponemal cellular components.