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Vasorelaxant response to acetylcholine in aortic rings of 4-week alloxan-diabetic rats treated with vehicle (saline) or D-chiro-inositol (20 mg/kg/12 h; p.o.). Data are mean SEM of 6 experiments. * p<0.05 (diabetic + D-chiro-inositol vs. diabetic + saline), # p<0.05 (normoglycemic vs. diabetic + D-chiro-inositol), ANOVA followed by Bonferroni.