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The Greek and Roman literature described phthisis, a common malady in poor and overcrowded areas leading to much morbidity and mortality. In 1837, phtisis was renamed Tuberculosis (TB), later also known as Koch’s disease. The cause of the disease remained long unknown, making effective treatment impossible.

Villemin described TB as infectious in 1865, and in 1882 Koch found the source of TB, the M. (Mycobacterium) Tuberculosis. R/ plans followed, based on a subdivision into open (infectious/ smear positive) and closed (non-infectious/ smear negative) tuberculosis.