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The following model is
proposed: GATA/HNF-1a synergy is mediated by
HNF-1a through its activation domains, which are
oriented for high levels of activation through a combination of binding to
DNA and physical association with GATA factors (Fig. 9). GATA/ HNF-1a
interactions might unmask the HNF-1a activation
domains either by a conformational change or by recruitment of additional
proteins that modulate transcriptional activity. Interaction between zinc
fingers and homeodomains may be.
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