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This table presents
the different types of HH, with the genes involved and the patterns of
inheritance. Beyond the main form, several rare types of HH may be distinguished: - HH type 2A is a juvenile form. The gene responsible is located on the long arm of chromosome 1 but remained unidentified at this time, - HH type 2B is a juvenile form linked to the HAMP gene (encoding for hepcidin), - HH type 3 is linked to theTfR2 gene (encoding for a second transferrin receptor), - HH type 4 is linked to the SLC11A3 gene (encoding for ferroportin, an intestinal iron transporter) - HH type 5 is linked to a gene encoding subunit H of ferritin. |