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Ferritin levels were positively correlated with AST and GGT levels (68 CHC patients) [57]. Together with serum aminotransferases, but not the pattern of HCV viremia in serum or in liver, they could predict the necroinflammatory activity in liver. However, these authors could not find any other laboratory parameter that was correlated with stage of fibrosis and considered liver biopsy obligatory to assess the disease activity [57]. On the overall, it is not clear whether this correlation merely reflects the presence of more active disease, or iron exacerbates chronic hepatitis C virus (HCV)-induced damage.